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Upper digestive and respiratory tract - Gents

Rates per 100,000 inhabitants

Table 1: Incidence: frequencies, crude and standardized rates per year

Incidence		1999	2000	2001	2002	2003	2004	2005	2006	1999‑2006
Count		214	221	212	185	198	201	202	188	1621
Crude rate		35.9	37.3	35.9	31.6	34.0	33.7	32.9	30.4	34.0 (32.3‑35.6)
Standardized rate	Italy 2001	34.4	35.9	35.1	30.1	32.3	31.5	32.2	29.7	32.6 (31.0‑34.3)
Standardized rate	Europe	26.9	28.0	25.4	22.6	24.7	24.5	24.4	22.4	24.8 (23.6‑26.1)
Standardized rate	World	19.1	20.1	17.8	16.0	17.4	17.5	17.0	16.0	17.6 (16.7‑18.5)

Table 2: Mortality: frequencies, crude and standardized rates per year

Mortality		1999	2000	2001	2002	2003	2004	2005	2006	1999‑2006
Count		85	94	92	72	71	73	99	72	658
Crude rate		14.2	15.9	15.6	12.3	12.2	12.2	16.1	11.6	13.8 (12.7‑14.9)
Standardized rate	Italy 2001	14.9	16.3	15.2	12.1	12.3	12.1	16.1	11.9	13.8 (12.7‑14.9)
Standardized rate	Europe	10.2	11.5	10.8	8.7	8.6	8.6	11.3	8.1	9.7 (8.9‑10.5)
Standardized rate	World	6.8	8.1	7.4	6.0	5.9	5.9	7.7	5.5	6.6 (6.1‑7.2)

Table 3: Register quality indicators per year

Indicator	1999	2000	2001	2002	2003	2004	2005	2006	1999‑2006
Mortality/Incidence ratio (%)	43.3	45.4	43.3	40.2	38.1	38.4	50.0	40.1	42.3
Cito-histologically confirmed (%)	95.8	96.4	96.7	99.5	97.0	95.5	97.5	95.2	96.7
Death certificate only - DCO (%)	0.0	1.4	0.5	0.0	1.5	0.5	1.0	1.1	0.7

Table 4: Comparison of Italian Registries mean prevalence by macro-areas

Graf 04

_	Milan	North West	North East	Centre	South	Italy
Incidence	24.0	24.5	25.9	18.5	17.6	22.7
Mortality	9.2	11.2	11.6	8.3	8.3	10.4

Table 5: Basis of diagnosis per period

_	1999‑2002	%	2003‑2006	%	1999‑2006	%
Histological	804	96.6	757	95.9	1561	96.3
Citological	3	0.4	3	0.4	6	0.4
Clinical	21	2.5	20	2.5	41	2.5
DCO	4	0.5	8	1.0	12	0.7

Table 6: More frequent morphologies

Morphology	N	%
Squamous cell carcinoma, NOS	597	78.6
Squamous cell carcinoma, keratinising, NOS	78	10.3
Carcinoma, undifferentiated, NOS	21	2.8
Squamous cell carcinoma, microinvasive	12	1.6
Carcinoma, NOS	11	1.4
Squamous cell carcinoma, large cell, non-keratinising, NOS	10	1.3

Table 7: Age distribution of rates

Graf 07

Age groups	Incidence	Mortality
0	0.0	0.0
1-4	0.0	0.0
5-9	0.0	0.0
10-14	1.1	0.0
15-19	0.0	0.0
20-24	1.9	0.0
25-29	0.0	0.0
30-34	2.7	0.4
35-39	4.8	1.7
40-44	8.5	2.5
45-49	23.2	7.9
50-54	42.1	14.3
55-59	72.2	20.7
60-64	83.6	33.8
65-69	80.1	21.8
70-74	92.7	40.8
75-79	86.6	37.4
80-84	92.2	54.6
85+	93.8	96.7

Table 8: Temporal trends of rates

Graf 08

Year	Mortality	Incidence
1999	10.2	26.9
2000	11.5	28.0
2001	10.8	25.4
2002	8.7	22.6
2003	8.6	24.7
2004	8.6	24.5
2005	11.3	24.4
2006	8.1	22.4

Table 10: Comparison of Italian Registries mean prevalence by macro-areas

Graf 10

Years since diagnosis	Italy	South	Centre	North East	North West	Milan
0-2	45.3	32.4	38.2	50.6	50.1	51.1
2-5	49.5	32.9	41.9	53.9	58.5	56.2
5-10	62.8	42.0	57.1	66.3	73.0	76.2
10-15	43.3	29.7	41.1	47.1	50.7	53.2
15-20	30.4	20.4	29.4	32.6	35.6	36.7
>20	43.9	28.2	43.3	46.8	49.8	53.5

Table 11: 5 years relative survival by macro-areas

Graf 11

Area	Relative survival (95% CI)
Milan	59.0 (55.1‑63.0)
North West	56.5 (54.5‑58.4)
North Est	53.7 (52.1‑55.3)
Centre	57.4 (54.5‑60.2)
South	55.0 (51.8‑58.1)
Italy	55.1 (54.0‑56.2)

Table 12: Relative survival by age since diagnosis

Age class	0	1	2	3	4	5
15-44	100.00	90.20	77.20	72.20	68.80	68.80
45-59	100.00	84.90	70.70	64.10	60.90	59.60
60-74	100.00	85.10	75.50	71.60	66.20	63.30
75+	100.00	81.90	72.20	66.20	60.70	60.30

Table 13: 5 years relative survival by biennium of incidence

Years since diagnosis	1999‑2000	2001‑2002	2003‑2004	2005‑2006
1	84.4	86.4	82.6	84.8
2	73.2	76.9	71	72.2
3	67	70.2	66.4	69.4
4	63.1	62.6	62.1	66.3
5	60.9	61.5	58.4	66.2

Table 14: Rates distribution by deprivation index

‑	1	2	3	4	5
Incidence	23.7	27.5	27	31.8	46.1
Mortality	7.4	8.8	12.5	13.5	20

Table 15: Relative survival by deprivation index

Years since diagnosis	Most deprived	Most affluent
0	100.0	100.0
1	79.3	91.8
2	65.6	81.4
3	62.9	79.5
4	56.4	74.0
5	53.2	72.1