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Leukaemias - Ladies

Rates per 100,000 inhabitants

Table 1: Incidence: frequencies, crude and standardized rates per year

Incidence		1999	2000	2001	2002	2003	2004	2005	2006	1999‑2006
Count		100	102	110	117	109	106	95	89	828
Crude rate		14.7	15.1	16.3	17.5	16.4	15.7	13.8	12.9	15.3 (14.3‑16.4)
Standardized rate	Italy 2001	12.2	11.9	13.0	14.0	12.4	12.3	10.7	9.8	12.0 (11.2‑12.9)
Standardized rate	Europe	9.6	8.9	10.0	11.3	9.3	9.6	8.1	7.1	9.2 (8.5‑10.0)
Standardized rate	World	7.7	7.0	7.7	9.6	7.6	7.9	6.6	5.1	7.4 (6.6‑8.2)

Table 2: Mortality: frequencies, crude and standardized rates per year

Mortality		1999	2000	2001	2002	2003	2004	2005	2006	1999‑2006
Count		73	70	71	72	83	62	80	70	581
Crude rate		10.7	10.4	10.5	10.8	12.5	9.2	11.7	10.1	10.7 (9.9‑11.6)
Standardized rate	Italy 2001	7.7	7.9	7.7	7.8	8.6	6.3	7.7	6.8	7.6 (7.0‑8.2)
Standardized rate	Europe	4.6	5.4	5.2	5.1	5.5	3.8	4.6	4.1	4.8 (4.4‑5.3)
Standardized rate	World	2.9	3.9	3.4	3.3	3.6	2.5	3.0	2.5	3.1 (2.8‑3.5)

Table 3: Register quality indicators per year

Indicator	1999	2000	2001	2002	2003	2004	2005	2006	1999‑2006
Mortality/Incidence ratio (%)	63.1	66.4	59.2	55.7	69.4	51.2	72.0	69.4	63.3
Cito-histologically confirmed (%)	95.0	89.2	91.8	94.9	91.7	93.4	90.5	89.9	92.2
Death certificate only - DCO (%)	3.0	3.9	1.8	4.3	5.5	1.9	5.3	9.0	4.2

Table 4: Comparison of Italian Registries mean prevalence by macro-areas

Graf 04

_	Milan	North West	North East	Centre	South	Italy
Incidence	8.5	7.2	7.7	8.3	8.0	7.8
Mortality	4.5	4.7	4.6	4.9	4.4	4.6

Table 5: Basis of diagnosis per period

_	1999‑2002	%	2003‑2006	%	1999‑2006	%
Histological	398	92.8	365	91.5	763	92.2
Citological	0	0.0	0	0.0	0	0.0
Clinical	17	4.0	12	3.0	29	3.5
DCO	14	3.3	21	5.3	35	4.2

Table 6: More frequent morphologies

Morphology	N	%
B-cell chronic leukaemia small lymphocytic lymphoma (see also M96703)	137	37.5
Acute myeloid leukaemia, NOS (FAB or WHO type not specified) (see also M99303)	118	32.3
Chronic myeloid leukaemia, NOS	30	8.2
Precursor cell lymphoblastic leukaemia, NOS (see also M97273)	14	3.8
Acute leukaemia, NOS	13	3.6
Chronic myelomonocytic leukaemia, NOS	8	2.2

Table 7: Age distribution of rates

Graf 07

Age groups	Incidence	Mortality
0	0.0	0.0
1-4	7.1	0.0
5-9	2.2	0.0
10-14	4.6	0.0
15-19	1.2	0.0
20-24	5.9	1.0
25-29	0.6	0.6
30-34	3.2	0.9
35-39	2.3	0.5
40-44	5.0	0.5
45-49	8.2	2.9
50-54	9.6	3.0
55-59	12.2	6.9
60-64	14.6	7.3
65-69	17.7	11.5
70-74	30.7	24.5
75-79	32.5	26.6
80-84	58.0	61.5
85+	71.5	75.4

Table 8: Temporal trends of rates

Graf 08

Year	Mortality	Incidence
1999	4.6	9.6
2000	5.4	8.9
2001	5.2	10.0
2002	5.1	11.3
2003	5.5	9.3
2004	3.8	9.6
2005	4.6	8.1
2006	4.1	7.1

Table 10: Comparison of Italian Registries mean prevalence by macro-areas

Graf 10

Years since diagnosis	Italy	South	Centre	North East	North West	Milan
0-2	14.5	14.2	17.0	13.7	14.3	16.3
2-5	15.8	14.0	15.7	15.9	17.0	21.0
5-10	18.8	19.0	15.6	19.0	20.6	21.8
10-15	12.0	11.1	9.5	12.6	13.1	11.9
15-20	6.6	8.0	6.1	6.5	6.2	7.0
>20	10.5	13.5	9.4	10.2	9.3	11.4

Table 11: 5 years relative survival by macro-areas

Graf 11

Area	Relative survival (95% CI)
Milan	45.8 (40.9‑50.7)
North West	44.6 (42.0‑47.2)
North Est	44.5 (42.1‑46.8)
Centre	43.7 (39.9‑47.5)
South	46.6 (42.7‑50.3)
Italy	44.8 (43.3‑46.2)

Table 12: Relative survival by age since diagnosis

Age class	0	1	2	3	4	5
15-44	100.00	83.70	77.20	75.40	71.90	71.90
45-59	100.00	79.30	65.20	60.30	57.90	54.60
60-74	100.00	69.40	62.50	60.60	56.50	51.80
75+	100.00	49.10	42.10	34.30	31.90	28.70

Table 13: 5 years relative survival by biennium of incidence

Years since diagnosis	1999‑2000	2001‑2002	2003‑2004	2005‑2006
1	67.3	65.7	62.8	62.7
2	60.7	56.7	55.7	53.9
3	57.1	52.1	49.4	49.9
4	50.2	50	48.5	47.8
5	45.1	47.2	42.6	47.8

Table 14: Rates distribution by deprivation index

‑	1	2	3	4	5
Incidence	13.7	14.1	13.4	17.4	12.8
Mortality	10.6	9.9	8.9	12.2	10.8

Table 15: Relative survival by deprivation index

Years since diagnosis	Most deprived	Most affluent
0	100.0	100.0
1	66.5	63.7
2	57.5	54.7
3	49.4	49.8
4	46.1	48.7
5	42.0	48.3