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Non Hodgkin - Ladies

Rates per 100,000 inhabitants

Table 1: Incidence: frequencies, crude and standardized rates per year

Incidence		1999	2000	2001	2002	2003	2004	2005	2006	1999‑2006
Count		170	172	159	160	163	157	165	168	1314
Crude rate		25.0	25.5	23.6	23.9	24.5	23.3	24.0	24.3	24.3 (23.0‑25.6)
Standardized rate	Italy 2001	20.5	20.2	18.7	18.3	18.8	17.9	19.1	19.1	19.0 (18.0‑20.1)
Standardized rate	Europe	15.2	14.5	14.0	13.3	13.9	12.9	14.4	14.0	14.0 (13.2‑14.9)
Standardized rate	World	11.2	10.4	10.0	9.5	10.1	9.3	10.7	10.2	10.2 (9.5‑10.9)

Table 2: Mortality: frequencies, crude and standardized rates per year

Mortality		1999	2000	2001	2002	2003	2004	2005	2006	1999‑2006
Count		71	92	76	73	95	71	77	75	630
Crude rate		10.4	13.6	11.3	10.9	14.3	10.5	11.2	10.9	11.6 (10.7‑12.6)
Standardized rate	Italy 2001	7.9	10.0	8.3	7.7	9.6	7.3	8.0	7.6	8.3 (7.6‑9.0)
Standardized rate	Europe	5.0	6.3	5.3	4.7	6.0	4.4	5.2	4.7	5.2 (4.8‑5.7)
Standardized rate	World	3.3	4.1	3.4	3.1	3.9	3.0	3.5	3.0	3.4 (3.1‑3.8)

Table 3: Register quality indicators per year

Indicator	1999	2000	2001	2002	2003	2004	2005	2006	1999‑2006
Mortality/Incidence ratio (%)	38.5	49.5	44.4	42.1	51.1	40.8	41.9	39.8	43.7
Cito-histologically confirmed (%)	98.8	96.5	98.1	95.6	94.5	96.2	97.6	95.2	96.6
Death certificate only - DCO (%)	0.6	0.6	0.0	1.9	2.5	1.3	1.2	0.6	1.1

Table 4: Comparison of Italian Registries mean prevalence by macro-areas

Graf 04

_	Milan	North West	North East	Centre	South	Italy
Incidence	13.8	14.1	13.1	11.2	10.7	12.4
Mortality	5.1	4.8	4.3	3.8	3.5	4.2

Table 5: Basis of diagnosis per period

_	1999‑2002	%	2003‑2006	%	1999‑2006	%
Histological	643	97.3	625	95.7	1268	96.5
Citological	0	0.0	1	0.2	1	0.1
Clinical	13	2.0	16	2.5	29	2.2
DCO	5	0.8	9	1.4	14	1.1

Table 6: More frequent morphologies

Morphology	N	%
Malignant lymphoma, large B-cell, diffuse, NOS	232	36.9
Malignant lymphoma, non-Hodgkin's, NOS	117	18.6
Follicular lymphoma, NOS (see also M96753)	67	10.7
Marginal zone B-cell lymphoma, NOS	54	8.6
Malignant lymphoma, small B lymphocytic, NOS (see also M98233)	23	3.7
Mycosis fungoides (C44._)	20	3.2

Table 7: Age distribution of rates

Graf 07

Age groups	Incidence	Mortality
0	0.0	0.0
1-4	0.0	0.0
5-9	1.1	0.0
10-14	1.1	1.1
15-19	1.2	0.0
20-24	4.9	1.0
25-29	3.2	0.6
30-34	5.6	0.5
35-39	5.9	0.9
40-44	10.0	1.5
45-49	14.6	1.8
50-54	16.8	2.4
55-59	26.5	6.4
60-64	32.4	12.0
65-69	37.5	16.1
70-74	65.5	24.5
75-79	67.1	39.8
80-84	72.7	54.6
85+	57.6	69.5

Table 8: Temporal trends of rates

Graf 08

Year	Mortality	Incidence
1999	5.0	15.2
2000	6.3	14.5
2001	5.3	14.0
2002	4.7	13.3
2003	6.0	13.9
2004	4.4	12.9
2005	5.2	14.4
2006	4.7	14.0

Table 10: Comparison of Italian Registries mean prevalence by macro-areas

Graf 10

Years since diagnosis	Italy	South	Centre	North East	North West	Milan
0-2	29.5	22.7	25.8	30.4	34.9	35.5
2-5	34.0	23.6	29.7	36.8	39.3	37.4
5-10	42.0	29.0	38.9	44.4	47.4	46.2
10-15	26.9	17.3	23.3	31.8	29.3	28.4
15-20	15.2	11.0	13.3	17.3	16.0	17.8
>20	25.7	18.1	23.3	28.0	28.7	29.9

Table 11: 5 years relative survival by macro-areas

Graf 11

Area	Relative survival (95% CI)
Milan	57.2 (54.3‑60.1)
North West	60.3 (58.4‑62.2)
North Est	63.7 (62.0‑65.3)
Centre	58.7 (55.6‑61.7)
South	53.5 (50.3‑56.5)
Italy	60.7 (59.6‑61.8)

Table 12: Relative survival by age since diagnosis

Age class	0	1	2	3	4	5
15-44	100.00	87.60	84.00	84.00	82.20	82.20
45-59	100.00	91.50	88.10	88.10	85.70	82.40
60-74	100.00	79.00	72.70	68.90	67.50	63.30
75+	100.00	57.10	46.20	42.50	39.70	37.30

Table 13: 5 years relative survival by biennium of incidence

Years since diagnosis	1999‑2000	2001‑2002	2003‑2004	2005‑2006
1	70.3	75.6	70.7	74.3
2	60.1	68.8	63.6	67.4
3	56.8	64.2	60.9	63.8
4	54.6	60.1	57.9	62
5	51.6	58.3	53.9	60.5

Table 14: Rates distribution by deprivation index

‑	1	2	3	4	5
Incidence	23.1	23.6	19.2	22	20.1
Mortality	11.3	10.9	9.5	12.8	12.1

Table 15: Relative survival by deprivation index

Years since diagnosis	Most deprived	Most affluent
0	100.0	100.0
1	73.8	73.5
2	66.7	65.8
3	63.8	62.5
4	61.5	59.8
5	58.6	56.6